Nirmitee.health

Patient-Centric Remote Data Capture

Collect Patient-Reported Outcomes Remotely With Clinera ePRO.

Bridge the distance between site visits with an offline-first web app that lets patients complete questionnaires, log medication diaries and report symptoms from their own smartphone or tablet.

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  • 94% Average Patient Compliance
  • Offline-First PWA
  • Zero App-Store Download
  • Automated Safety Alerting
Clinera ePRO module dashboard showing submission tracking, form templates, assessment schedules and compliance analytics.

Product Overview

Replace Paper Diaries With Real-Time Patient Data.

Traditional trials still rely on paper diaries and retrospective questionnaires filled in during site visits. Clinera ePRO moves patient data collection onto the participant's own device, so capture happens in real time and engagement holds across the study lifecycle.

01

Real-Time Data Capture

Responses are timestamped at submission, inside the protocol window they belong to.

02

No App Download Required

A tokenized SMS or email link opens the form in the browser. No store listing, account setup or version mismatch across a cohort.

03

Automated Safety Alerts

Threshold breaches escalate to the CRC and PI the moment a participant submits, instead of waiting for the next site visit.

04

Direct EDC Integration

ePRO responses flow into the Clinera EDC subject record without manual re-entry or reconciliation spreadsheets.

Capabilities

Core Features and Capabilities.

Five feature blocks cover the full remote capture chain: instruments, reminders, offline completion, safety escalation and the coordinator dashboard.

Feature 01

Validated Patient Instrument Library and Custom eDiaries

Clinera ePRO ships with standardized patient-reported outcome measures and supports fully custom clinical diaries built to your protocol.

  • Quality of Life Instruments - Pre-configured templates for EQ-5D-5L, FACIT, SF-36 and QoL-C30.
  • Oncology and Symptom Questionnaires - PRO-CTCAE instruments for patient-reported adverse-event severity scoring.
  • Visual Analog Scales and Rating Grids - Interactive touch sliders for pain intensity, fatigue, nausea and mood.
  • Daily Medication Adherence Logs - Time-stamped dosing confirmation, meal timing logs and pill count tracking.

Feature 02

Multi-Channel Automated Nudges and Dispatch Engine

Never lose patient data to a forgotten survey window. Protocol logic determines when forms dispatch, which channel is used, and when a window closes.

  • Automated Dispatch Rules - Fire forms on protocol logic: daily at 08:00, Day 7 post-dose, or every Monday.
  • Omnichannel Reminders - SMS, WhatsApp, email and native push, sent on your escalation ladder.
  • Strict Compliance Windows - Define active response windows so timestamps stay authentic and back-filling is blocked.

Feature 03

Offline-First Progressive Web App Architecture

Remove the technical barriers that stop participants reporting at all, even when signal quality is poor.

  • No App-Store Download - A secure tokenized link from SMS or email opens the questionnaire instantly in the browser.
  • Offline Resilience - Participants can complete forms without signal. Responses are encrypted locally and synced when connectivity returns.
  • Universal Device Support - Adapts across iOS, Android, tablets and desktop browsers without a separate build.

Feature 04

Real-Time Safety Alerts and Symptom Escalation

Turn patient feedback into immediate clinical action with automated scoring and site-team escalation.

  • Automated Symptom Scoring - Total scores are calculated and threshold triggers evaluated the instant a form is submitted.
  • Alert Escalation - Severe reports dispatch urgent SMS and email alerts to the Clinical Research Coordinator and Principal Investigator.
  • Emergency Prompt - Configurable emergency instructions and a site hotline call button appear on the patient's screen when severe criteria are met.

Feature 05

Real-Time Compliance Analytics and Coordinator Dashboard

Give site staff complete visibility into remote adherence, subject by subject, without leaving the study workspace.

  • Site Compliance Heatmap - Color-coded completion rates in real time, per subject, per visit and per form.
  • Proactive Coordinator Nudges - Send a manual SMS or WhatsApp follow-up to a struggling subject directly from the workspace.

Workflow

Role-Based Workflow and Benefits.

Each role gets a different view of the same study. Patients see a short form. Coordinators see adherence and safety alerts. Investigators and sponsors see the outcome data next to the eCRF.

RoleKey Capabilities in Clinera ePROKey Benefit

Trial Participant

Complete short, friction-free forms on a personal phone, receive automated reminders and work offline.

Easy participation without burdensome site visits.

Coordinator (CRC)

Track subject adherence live, receive instant safety alerts and dispatch extra form instances.

Visibility into patient wellbeing between scheduled visits.

Investigator (PI)

Review patient-reported outcomes alongside eCRFs and evaluate safety alert trends across arms.

High-fidelity outcome data for clinical evaluation.

Sponsor / Monitor

Analyze cross-site compliance, assess daily and weekly endpoint trends and verify retention.

Higher data quality, zero recall bias and improved patient retention.

Why Clinera ePRO

What Makes Clinera ePRO Different.

01

Access Without Installation

Native ePRO apps lose participants at the download step, particularly in older cohorts and low-bandwidth sites. A tokenized browser link removes that drop-off while keeping the session secure.

02

Offline Without Data Loss

Connectivity gaps are common in the field. Responses are encrypted in local browser storage and synced on reconnect, so a lost signal does not become a missing entry.

03

Verified Submission Timestamps

Protocol-defined windows lock each form open and shut. A week of diaries cannot be back-filled on Sunday night, and the submission record holds up under audit.

Specifications

Technical and Regulatory Compliance.

Clinera ePRO is deployed as part of the Clinera platform and inherits its security, audit and integration model.

Data Privacy and Security
HIPAA compliant, GDPR compliant, 256-bit AES encryption in transit and at rest.
Compliance Window Controls
Cryptographic submission timestamps prevent retroactive form alteration or back-filling.
Multilingual Localization
Dynamic multi-language support with instant form translation into 30+ regional languages for global multi-center trials.
Direct EDC Integration
Submitted ePRO data flows automatically into the central Clinera EDC subject record, eliminating manual re-entry.
Delivery Model
Offline-first Progressive Web App. No app-store submission, no per-device install and no version mismatch across a cohort.
Notification Channels
SMS, WhatsApp, email and native push, configurable per study, per form and per escalation step.

FAQ

Frequently Asked Questions.

Do Patients Need to Download an App From the App Store or Google Play?+

No. Clinera ePRO runs as an offline-first Progressive Web App. Participants tap a secure, tokenized link received by SMS or email and the form opens instantly in their browser.

What Happens if a Patient Loses Internet Connection Mid-Diary?+

All progress is saved locally on the device in encrypted browser storage. Once connectivity is re-established, the responses sync to the server automatically, with no re-entry required from the participant.

How Does Clinera ePRO Stop Patients Filling in a Week of Diaries on Sunday Night?+

Protocol-defined compliance windows. Daily forms are only accessible during their designated window, for example 07:00 to 23:00 on that specific day, and lock automatically afterwards. This preserves real-time data integrity.

Next Step

Schedule a Clinera ePRO Demo.

Bring one visit schedule and one instrument. We will configure the dispatch rules, compliance windows and safety thresholds live on the call.

Book a 30-min walkthrough